vacuolar protein sorting-associated protein 37B (hVps37B) (VPS37B)

Function

• component of the ESCRT1 complex, a regulator of vesicular trafficking process
• required for sorting of endocytic ubiquitinated cargos into multivesicular bodies
• interacts with TSG101

Structure

belongs to the VPS37 family contains 1 VPS37 C-terminal domain

Compartment

• cytoplasm
• late endosome
• peripheral membrane
• recruited to the endosomal membrane (VPS4A-dependent)

Expression

• widely expressed
• expressed in macrophages & lymphocytes

More general terms

• membrane protein
• vacuolar protein sorting-associated protein (VPS)

Component of

• endosomal sorting complex required for transport-1 (ESCRT1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H9H4.html