NUT family member 1; nuclear protein in testis (NUTM1, C15orf55, NUT)

Function

• phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export

Structure

belongs to the NUT family

Compartment

• cytoplasm, nucleus.
• shuttles between nucleus & cytoplasm

Alternative splicing

named isoforms=2

Expression

specifically expressed in testis

Pathology

• chromosomal translocation t(15;19)(q14;p13) involving NUT with BRD4 is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
  • translocation produces a BRD4-NUT fusion protein
• chromosomal translocation t(15;19)(q14;q34) involving NUT with BRD3 is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
  • translocation produces a BRD3-NUT fusion protein

More general terms

• Nut family protein
• phosphoprotein

Additional terms

• nuts (food nut, dietary nut, nut consumption)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=256646
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:256646
• OMIM: https://mirror.omim.org/entry/608963
• UniProt: http://www.uniprot.org/uniprot/Q86Y26.html