trafficking protein particle complex subunit 9; NIK- & IKBKB-binding protein; Tularik gene 1 protein (TRAPPC9, KIAA1882, NIBP)

Function

• functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex
• may function in neuronal cells differentiation
• role in vesicular transport from endoplasmic reticulum to Golgi
• component of the multisubunit TRAPP complex
• directly interacts with IKBKB & MAP3K14

Structure

belongs to the NIBP family

Compartment

• Golgi, cis-Golgi network
• endoplasmic reticulum (putative)
• cytoplasm
• processes & cell bodies of neurons

Alternative splicing

named isoforms=3

Expression

• expressed at high levels in muscle & kidney
• expressed to a lesser extent in brain, heart & placenta

Pathology

• mutations in TRAPPC9 are the cause of autosomal recessive mental retardation 13

More general terms

• protein subunit

Component of

• transport protein particle complex (TRAPP complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83696
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83696
• OMIM: https://mirror.omim.org/entry/611966
• OMIM: https://mirror.omim.org/entry/613192
• UniProt: http://www.uniprot.org/uniprot/Q96Q05.html