levomilnacipran (Savella)
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Introduction
see milnacipran
Dosage
- start 20 mg
- max 120 mg
Tabs: 20, 40, 80, 120 mg sustained release release tablets
Dosage adjustment in renal failure
- max dose
- 80 mg daily with moderate renal impairment
- 40 mg daily with severe renal impairment
Pharmacokinetics
Monitor
Drug interactions
- concurent use of strong CYP3A4 inhibitors (ketoconazole ...) increase levels of levomilnacipran
- drug interaction(s) of antidepressant in combination with GLP1-agonist
- drug interaction(s) of triptans with SNRIs
- drug interaction(s) of methylene blue with SNRIs
- drug interaction(s) of linezolid with SNRIs
- drug interaction(s) of benzodiazepines with antidepressants
- drug interaction(s) of antidepressants with benzodiazepines
- drug interaction(s) of NSAIDs with antidepressants
- drug interaction(s) of antidepressant with opiates
Mechanism of action
- stronger inhibition of norepinephrine reuptake than serotonin reuptake
More general terms
References
- ↑ RxNorm
- ↑ Prescriber's Letter 20(12): 2013 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=291206&pb=PRL Comparison of Antidepressants (subscription needed) http://www.prescribersletter.com