combination of ACE inhibitor/angiotension 2 receptor antagonist

Introduction

Randomized, double-blind, cross-over trial

Study:

• 24 type 1 diabetics with:
  • albuminuria > 300 mg/day
  • retinopathy
• base-line serum creatinine 1.5 mg/dL (mean)
• all patients receive 40 mg of enalapril/day
• irbesartan 300 mg/day for 8 weeks vs placebo
• cross-over at 8 weeks (placebo with irbesartan)

Results:

• albuminuria reduced 25% during dual blockade
• mean blood pressure lower during dual blockade
  • 8 mm Hg systolic, 8 mm Hg diastolic

More general terms

• antihypertensive combination

Components

• angiotensin-converting enzyme (ACE) inhibitor
• angiotensin II receptor antagonist (ARB)