ranibizumab ophthalmic (Lucentis, Byooviz)
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Introduction
Tradename: Lucentis (FDA approved 2006).
Aslo see more general term ranibizumab
Indications
Dosage
- intavitreal injection of 0.3-0.5 mg monthly
Adverse effects
- conjunctival hemorrhage
- eye pain
- floaters
- increased intra-ocular pressure[2]
- ophthalmitis
- retinal detachment[2]
Mechanism of action
- angiogenesis inhibitor, binds to & inhibits VEGF
Notes
- cost $2000/0.5 mg dose
- according to the Washington Post, this is the same drug as bevacizumab (Avastin) both produced by Genentech[3]
More general terms
References
- ↑ Rosenfeld PJ et al Ranibizumab for neovascular age-related macular degeneration N Engl J Med 2006, 355:1419 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17021318
Brown DM et al Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006, 355:1432 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17021319
Steinbrook R. The price of sight - Ranibizumab, bevacizumab, and the treatment of macular degeneration. N Engl J Med 2006, 355:1409 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17021315
Stone EM. A very effective treatment for neovascular macular degeneration N Engl J Med 2006, 355:1493 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17021326 - ↑ 2.0 2.1 2.2 2.3 FDA News Release: Aug. 10, 2012 FDA approves Lucentis to treat diabetic macular edema http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm315130.htm
- ↑ 3.0 3.1 Kliff S This $2,000 drug says everything about our messed up health- care system. Washington Post Dec 9, 2013 http://www.washingtonpost.com/blogs/wonkblog/wp/2013/12/09/this-2000-drug-says-everything-about-our-messed-up-health-care-system/
- ↑ 4.0 4.1 The Diabetic Retinopathy Clinical Research Network. Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema. N Engl J Med. 2015 Feb 18. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25692915 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1414264
Martin DF, Maguire MG. Treatment Choice for Diabetic Macular Edema. N Engl J Med. 2015 Feb 18. [Epub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25692914 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMe1500351