idoxuridine ophthalmic (Herplex, Stoxil)

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Introduction

Tradenames: Herplex, Stoxil.

Indications

treatment of Herpes simplex keratitis

Dosage

  • 1 drop into affected eye every hour during day & every 2 hours at night, until improvement
  • then, 1 drop every 2 hours during day & every 4 hours at night
  • continue for 5-7 days after healing
  • recurrences are more likely to occur is treatment is not continues 3-7 days after healing appears complete
  • if no response in 14 days, consider another agent

Ointment: 0.5% (4 g)

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Database