disease interaction(s) of osteoporosis with chronic renal failure

Introduction

Interactions;

• renal osteodystrophy occurs in a population that includes patients with osteoporosis

Laboratory

• serum parathyroid hormone may be elevated with renal osteodystrophy

Radiology

• bone mineral density may not distinguish renal osteodystrophy from osteoporosis

Management

• bisphosphonate dose should be reduced in patients with GFR < 30 mg/mL/1.73 mg2
• bisphosphonate may reduce bone loss in renal transplant patients, but effects on fracture risk are unclear
• raloxifene may reduce risk of vertebral fractures, but not increase bone mineral density
• effects of teriparatide & on bone mineral density & fracture risk are unclear
• see renal osteodystrophy & osteoporosis

More general terms

• disease interaction