ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (USP17L18)

Function

• deubiquitinating enzyme
• removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, & the cellular response to viral infection (putative)
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

• belongs to the peptidase C19 family, USP17 subfamily

Compartment

• nucleus (putative)
• endoplasmic reticulum (putative)

Genetics

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene
• it is present with an interindividual variation in copy number, ranging from 20-103, & can be found in the genome on chromosome 4 & chromosome 8
• the high similarity between the UPS17-like genes makes it difficult to specifically assign data to a particular gene of the family, oligonucleotides designed in RNAi experiments are for instance not specific for a given UPS17-like gene

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100287
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100287
• UniProt: http://www.uniprot.org/uniprot/D6R9N7.html