chronic myelogenous leukemia genotyping

Genetics

• associated genetic aberrations:
  • chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome)

Indications

• chronic myelogenous leukemia

Methods

bcr/abl mRNA by RT-PCR

Specimen

• bone marrow
• whole blood (ACD or EDTA)
• store body fluid at 4 degrees C
• store tissue at -20 degrees C or below

More general terms

• genotyping (allele testing)

More specific terms

• BCR-ABL1 fusion protein in blood/tissue

Additional terms

• chromosomal translocation t9q34.1:22q11 (Philadelphia chromosome; bcr/abl)
• chronic myeloid leukemia (CML, granulocytic leukemia)