paternal age
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Notes
- spontaneous genetic mutations occur during spermatogenesis & are passed on to children
- most spontaneous genetic mutations come from the father
- the rate of spontaneous genetic mutation increases with the father's age at conception
- paternal age is a risk factor for autism & schizophrenia
- advancing paternal age is associated with increased risk of psychiatric & academic morbidity[2]
- paternal age >= 45 years associated with premature birth, lower Apgar scores, admission to neonatal ICU[3]
- also associated with increased risk of gestational diabetes in mothers (may be due to placental health)
References
- ↑ Physician's First Watch, Aug 27 2012 Massachusetts Medical Society http://www.jwatch.org
Kong A et al Rate of de novo mutations and the importance of father's age to disease risk Nature 488, 471-475 (23 August 2012) <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22914163 <Internet> http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html
Kondrashov A Genetics: The rate of human mutation Nature 488, 467-468 (23 August 2012) <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22914161 <Internet> http://www.nature.com/nature/journal/v488/n7412/full/488467a.html - ↑ 2.0 2.1 D'Onofrio BM et al. Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry 2014 Feb 26 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24577047 <Internet> http://archpsyc.jamanetwork.com/article.aspx?articleid=1833092
- ↑ 3.0 3.1 Khandwala YS, Baker VL, Shaw GM et al Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study. BMJ 2018;363:k4372 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30381468 Free full text https://www.bmj.com/content/363/bmj.k4372
Brown HK Paternal factors in preconception care: the case of paternal age. BMJ 2018;363:k4466 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30381463 https://www.bmj.com/content/363/bmj.k4466