GAGE-2D protein; GAGE-8 protein; G antigen 2D; GAGE-2D; cancer/testis antigen 4.8; CT4.8; G antigen 8; GAGE-8 (GAGE2D)

Function

• antigen
  • recognized on melanoma by autologous cytolytic T-cells (see Genetics:)

Structure

belongs to the GAGE family

Expression

• exressed specifically in testis

Pathology

• expressed in several tumor tissues including melanoma

Genetics

• gene belongs to a family of genes organized in clustered repeats
  • the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
  • their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

More general terms

• GAGE protein (G antigen family)
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100101
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=729408
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100101
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:729408
• OMIM: https://mirror.omim.org/entry/300638
• OMIM: https://mirror.omim.org/entry/300735
• UniProt: http://www.uniprot.org/uniprot/Q9UEU5.html