GAGE-2B protein; G antigen 2B; G antigen 2B/2C; GAGE-2B; GAGE-2C; cancer/testis antigen 4.2; CT4.2; G antigen 2C (GAGE2B, GAGE2, GAGE2C)

Function

• antigen
  • recognized on melanoma by autologous cytolytic T-cells (see Genetics:)
• completely silent in normal adult tissues, except testis

Structure

belongs to the GAGE family

Expression

• exressed specifically in testis

Pathology

• expressed in several tumor tissues including melanoma

Genetics

• gene belongs to a family of genes organized in clustered repeats
  • the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
  • their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

More general terms

• GAGE protein (G antigen family)
• phosphoprotein
• testis-specific protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2574
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2574
• OMIM: https://mirror.omim.org/entry/300595
• OMIM: https://mirror.omim.org/entry/300726
• UniProt: http://www.uniprot.org/uniprot/Q13066.html