tropical calcific pancreatitis

Introduction

idiopathic, juvenile, nonalcoholic form of chronic pancreatitis

Etiology

• can be associated with fibrocalculous pancreatic diabetes depending on both environmental & genetic factors

Epidemiology

• widely prevalent in several tropical countries

Genetics

• associated with defects in SPINK1

Complications

• exceptionally high incidence of pancreatic cancer

Differential diagnosis

• differs from alcoholic pancreatitis by
  • a much younger age of onset
  • pancreatic calcification
  • high incidence of insulin dependent but ketosis resistant diabetes mellitus
  • an exceptionally high incidence of pancreatic cancer

More general terms

• chronic pancreatitis
• genetic disease of the gastrointestinal tract

Database

• OMIM: https://mirror.omim.org/entry/608189