serine protease inhibitor Kazal-type 1; pancreatic secretory trypsin inhibitor; tumor-associated trypsin inhibitor; TATI (SPINK1, PSTI)

Function

• prevents trypsin-catalyzed premature activation of zymogens within the pancreas

Structure

contains 1 Kazal-like domain

Compartment

secreted

Pathology

• defects in SPINK1 are a cause of chronic pancreatitis
• defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis

More general terms

• Kazal type serine protease inhibitor
• trypsin inhibitor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6690
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6690
• OMIM: https://mirror.omim.org/entry/167790
• OMIM: https://mirror.omim.org/entry/167800
• OMIM: https://mirror.omim.org/entry/608189
• UniProt: http://www.uniprot.org/uniprot/P00995.html