linear IgA disease
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Pathology
- subepidermal blistering disorder
- tissue-bound & circulating IgA autoantibodies to the dermal-epidermal junction
- both the 120 kD linear IgA disease antigen & the 97 kD linear IgA disease antigen of COL17A1, represent major antigenic targets of autoantibodies in patients with linear IgA disease
- the IgA autoantibodies preferentially react with 97 kD & the 120 kD forms, but not with the full-length COL17A1, suggesting that the cleavage of the ectodomain generates novel autoantigenic epitopes
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UMD9.html
- ↑ 2.0 2.1 ARUP Consult: Linear IgA Disease The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/linear-iga-disease
- ↑ Chaudhari S, Mobini N. Linear IgA Bullous Dermatosis: A Rare Clinicopathologic Entity with an Unusual Presentation. J Clin Aesthet Dermatol. 2015 Oct;8(10):43-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26557220 Free PMC Article
- ↑ Chen S, Mattei P, Fischer M, Gay JD, Milner SM, Price LA. Linear IgA bullous dermatosis. Eplasty. 2013 Jul 2;13:ic49. Print 2013. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23882302 Free PMC Article
- ↑ Haeberle MT, James WD Linear IgA Dermatosis Medscape: (eMedicine) https://emedicine.medscape.com/article/1063590-overview