drug interaction(s) of angiotensin II receptor antagonists with aliskiren
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Drug interactions
- aliskiren potentiates adverse effects of ACE inhibitors:[3]
- symptomatic hypotension
- renal failure
- hyperkalemia
- combining ACE inhibitor or ARB with aliskiren increases risk of stroke, renal complications, hyperkalemia, & hypotension in some patients with diabetes mellitus[2]
More general terms
References
- ↑ Prescriber's Letter 19(2): 2012 COMMENTARY: Combination Therapy for Hypertension CHART: Antihypertensive Combinations Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280224&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 2.0 2.1 Harel Z et al. The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: Systematic review and meta-analysis. BMJ 2012 Jan 9; 344:e42 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22232539
- ↑ 3.0 3.1 Makani H et al Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ 2013;346:f360 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23358488 <Internet> http://www.bmj.com/content/346/bmj.f360