stress-responsive DNAJB4-interacting membrane protein 1 (SDIM1)

Function

• promotes neuronal cells survival to stress conditions
• interacts with DNAJB4

Structure

homodimer

Compartment

membrane (potential)

Expression

• expressed in brain with higher detection in neurons than astrocytes
• decreased expression in Alzheimer brains
• detected at protein level in brain & cervix
• down-regulated in NT2 neurons subjected to stress conditions which triggers neuronal apoptosis such as oxygen & glucose deprivation, followed by up-regulation in surviving cells

More general terms

• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100505
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100505
• UniProt: http://www.uniprot.org/uniprot/Q6ZPB5.html