kell blood group glycoprotein; CD238 (KEL)

Function

• Zn+2 endopeptidase with endothelin-3-converting enzyme activity
• heterodimer with XK; disulfide-linked

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• belongs to the peptidase M13 family

Compartment

• cell membrane; single-pass type 2 membrane protein
• spans the erythrocyte membrane, & is attached to the underlying cytoskeleton

Polymorphism

• KEL is responsible for the kell blood group system

More general terms

• zinc metalloprotease
• glycoprotein

Additional terms

• Kell blood group antigen (kell blood group system, KEL)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3792
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3792
• OMIM: https://mirror.omim.org/entry/110900
• UniProt: http://www.uniprot.org/uniprot/P23276.html