Kell blood group Kx antigen (precursor substance, Kx antigen, Kell complex 37 kD component, XK-related protein 1, XK, XKR1, XRG1)

Function

• role in Na+-dependent transport of neutral amino acids or oligopeptides
• not glycosylated

Structure

belongs to the XK family

Compartment

membrane

Expression

• expressed in skeletal muscle, heart, brain & pancreas > placenta, lung, liver, & kidney

Pathology

• defects in XK are the cause of McLeod syndrome

Polymorphism

• XK is responsible for the Kx blood group system

More general terms

• plasma membrane protein
• antigen
• XK family
• transmembrane 10 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7504
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7504
• OMIM: https://mirror.omim.org/entry/314850
• UniProt: http://www.uniprot.org/uniprot/P51811.html