hydralazine/isosorbide dinitrate (BiDiL)

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Indications

Dosage

1-2 tabs PO TID (8-12 hour nitrate-free interval overnight)

Tabs: 37.5 mg hydralazine & 20 mg isosorbide dinitrate

Adverse effects

Mechanism of action

Notes

Cost up to $400/month, compared to $60/month for the two generic drugs separately.

More general terms

Components

References

  1. American Medical News
  2. Prescriber's Letter 12(1):2, 2005 Isosorbide Dinitrate Plus Hydralazine in Blacks with Heart Failure Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210105&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. 3.0 3.1 Prescriber's Letter 12(8): 2005 New Formulation: BiDil (Isosorbide Dinitrate and Hydralazine Hydrochloride) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210808&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 Taylor AL, Ziesche S, Yancy C et al Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351(20);2049-2057 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15533851 Free article