Heartland virus
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Epidemiology
- first identified in Missouri in 2009,
- cases reported in Midwestern & southern states
- transmitted bu Lone Star tick
- two cases in 2012, both occurring after exposure to ticks on farmland in Missouri
- Lone star ticks are common in Missouri, & in genera in the South & the Atlantic coast of the U.S.
- virus is circulating in lone star ticks in Georgia, 2021[3]
Clinical manifestations
- headache, myalgia, arthragia, fatigue, malaise, anorexia, fever
- nonbloody diarrhea
- clinically indistinguishable from Ehrlichiosis[2]
Laboratory
- complete blood count; thrombocytopenia, leukopenia
- elevated serum AST & serum ALT
Differential diagnosis
- Ehrlichiosis responds rapidly to doxycycline with fever defervescence[2]
Management
- doxycycline not effective
More general terms
References
- ↑ Physician's First Watch, Aug 30, 2012 Massachusetts Medical Society http://www.jwatch.org
McMullan LK et al A New Phlebovirus Associated with Severe Febrile Illness in Missouri N Engl J Med 2012; 367:834-841August 30, 2012 http://www.nejm.org/doi/full/10.1056/NEJMoa1203378 - ↑ 2.0 2.1 2.2 Medical Knowledge Self Assessment Program (MKSAP) 19. American College of Physicians, Philadelphia 2021
- ↑ 3.0 3.1 Crist C Tick-Borne Heartland Virus Circulating in US, Researchers Say. Medscape. March 24, 2022 https://www.medscape.com/viewarticle/970910
Romer Y, Adcock K, Wei Z, et al. Isolation of Heartland Virus from Lone Star Ticks, Georgia, USA, 2019. Emerging Infectious Diseases. 2022;28(4):786-792. https://wwwnc.cdc.gov/eid/article/28/4/21-1540_article