microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; actin cross-linking family protein 7; macrophin-1; trabeculin-alpha; 620 kD actin-binding protein; ABP620 (MACF1, ABP620, ACF7, KIAA0465, KIAA1251)

Function

• F-actin-binding protein
• may play a role in cross-linking actin to other cytoskeletal proteins
• also binds to microtubules (putative)

Structure

• belongs to the plakin or cytolinker family
• contains 1 actin-binding domain
• contains 2 CH (calponin-homology) domains
• contains 2 EF-hand domains
• contains 1 GAR domain
• contains 1 SH3 domain
• contains 37 spectrin repeats

Compartment

cytoplasm, cytoskeleton

Alternative splicing

named isoforms=5

Expression

ubiquitously expressed

More general terms

• microtubule-actin cross-linking factor 1 (macrophin 1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23499
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23499
• OMIM: https://mirror.omim.org/entry/608271
• UniProt: http://www.uniprot.org/uniprot/Q9UPN3.html