microtubule-actin cross-linking factor 1 (macrophin 1)

Function

• cross-linking cytoskeletal proteins
• binds intermediate filaments to N-terminal plectin repeats & microtubules to C-terminus

Structure

• contains EF-hand domains
• contains plectin repeats
• contains spectrin repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• expressed in heart, lung, pituitary & placenta
• not exressed in brain, kidney, liver, pancreas or skeletal muscle

More general terms

• cytoskeletal protein
• Ca+2 binding protein
• phosphoprotein

More specific terms

• microtubule-actin cross-linking factor 1, isoform 4 (macrophin 1, trabeculin-alpha, cross-linking factor 7, MACF1, ABP620, ACF7, KIAA0465, KIAA1251)
• microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; actin cross-linking family protein 7; macrophin-1; trabeculin-alpha; 620 kD actin-binding protein; ABP620 (MACF1, ABP620, ACF7, KIAA0465, KIAA1251)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23499
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23499
• OMIM: https://mirror.omim.org/entry/608271
• UniProt: http://www.uniprot.org/uniprot/Q9UPN3.html