microtubule-actin cross-linking factor 1, isoform 4 (macrophin 1, trabeculin-alpha, cross-linking factor 7, MACF1, ABP620, ACF7, KIAA0465, KIAA1251)

Function

• cross-linking cytoskeletal proteins
• binds intermediate filaments to N-terminal plectin repeats & microtubules to C-terminus
• contains 2 EF-hand domains
  • contains 19 plectin repeats
  • contains 32 spectrin repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• expressed in heart, lung, pituitary & placenta
• not exressed in brain, kidney, liver, pancreas or skeletal muscle

Notes

• entry removed from UniProt 5/9/12

More general terms

• microtubule-actin cross-linking factor 1 (macrophin 1)

Database

• OMIM: https://mirror.omim.org/entry/608271