Nexilin (F-actin binding protein, Nelin, NEXN)

Function

• role in regulating cell migration through association with the actin cytoskeleton
• interacts with F-actin

Structure

contains 1 Ig-like (immunoglobulin-like) domain

Compartment

• cytoplasm, cytoskeleton, cell junction, adherens junction (putative)
• localizes to the cell-matrix AJ
• not found at the cell-cell AJ (putative)

Alternative splicing

named isoforms=3

Expression

• abundantly expressed in heart & skeletal muscle, & at lower levels in placenta, lung, liver & pancreas
• also expressed in HeLa S3 & Molt-4 cells

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q0ZGT2.html