BBsome complex

Function

• required for ciliogenesis
• dispensable for centriolar satellite function
• ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body & contacts the BBsome Rab8(GTP) enters the primary cilium & promotes extension of the ciliary membrane
• 1st the BBsome associates with the ciliary membrane & binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 & then the Rab8-GTP localizes to the cilium & promotes docking & fusion of carrier vesicles to the base of the ciliary membrane
• binds to PCM1 & tubulin

Structure

• subunits inlcude BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 & BBIP10

More general terms

• molecular complex