sialic acid-binding Ig-like lectin 12; siglec-12; sialic acid-binding Ig-like lectin-like 1; siglec-L1 (SIGLEC12, SIGLECL1, SLG, UNQ9215/PRO34042)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 2 Ig-like V-type domains (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

• long (SLG-L), short (SLG-S)

Expression

• isoform short is highly expressed in spleen, small intestine & adrenal gland; lower expression in thyroid, placenta, brain, stomach, bone marrow, spinal cord & breast
• isoform long is highly expressed in spleen, small intestine & bone marrow; lower expression in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain & testis

More general terms

• sialic acid-binding immunoglobulin-like lectin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89858
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:89858
• OMIM: https://mirror.omim.org/entry/606094
• UniProt: http://www.uniprot.org/uniprot/Q96PQ1.html