zinc finger protein 593; zinc finger protein T86 (ZNF593)

Function

• negatively modulates the DNA binding activity of Oct-2 & thus its transcriptional regulatory activity
• could act either by binding to DNA octamer or by interacting with Oct-2
• may also be a modulator of other octamer-binding proteins

Structure

• the protein is largely disordered, with the exception of the Zn+2 finger domain
• belongs to the ZNF593/BUD20 C2H2-type Zn+2-finger protein family
• contains 1 C2H2-type Zn+2 finger

Compartment

nucleus, nucleolus

Expression

• ubiquitous
• detected in spleen, prostate, testis, small intestine, colon > thymus, peripheral blood leukocytes

More general terms

• C2H2 type zinc finger protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51042
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51042
• UniProt: http://www.uniprot.org/uniprot/O00488.html