morphine/naltrexone (Embeda)

From Aaushi
Jump to navigation Jump to search

Introduction

Capsules containing extended-release morphine pellets with an inner core of the opioid antagonist naltrexone

Indications

Dosage

  • QD or BID dosing
  • capsules can be opened & the pellets sprinkled on applesauce
  • do NOT crush

Capsules:

Pharmacokinetics

Adverse effects

Drug interactions

Notes

costs $250 to $850 for 60 caps (2009)

More general terms

References

  1. Prescriber's Letter 16(10): 2009 New Drug: Embeda (Morphine/Naltrexone) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=251009&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. FDA News Release. October 17, 2014 FDA approves labeling with abuse-deterrent features for third extended-release opioid analgesic http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm419288.htm
  3. EMBEDA Prescribing Information http://labeling.pfizer.com/ShowLabeling.aspx?id=694