Whipple's triad (Whipple's criteria)

Etiology

• hypoglycemia (insulinoma)

Clinical manifestations

• symptoms are known or likely to be caused by hypoglycemia
  • cholinergic symptoms
    • sweating
  • adrenergic symptoms
    • anxiety
    • tachycardia
    • tremulousness
  • neurologic symptoms
    • headache
    • behavioral changes (combativeness, agitation)
• a low serum glucose measured at the time of symptoms
• relief of symptoms when the glucose is raised to normal

More general terms

• triad
• criteria

Additional terms

• intestinal lipodystrophy (Whipple's disease)
• pancreatoduodenectomy (Whipple procedure)