exfoliation syndrome (exfoliation glaucoma)

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Pathology

Genetics

  • genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome
  • susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu & Gly153Asp) & one intronic SNP
  • Arg141Leu & Gly153Asp are sufficient to confer disease susceptibility in some populations

More general terms

References

Database