Lysyl oxidase homolog 1; Lysyl oxidase-like protein 1; LOL (LOXL1, LOXL)

Function

• active on elastin & collagen substrates

Cofactor: Copper

Structure

• contains 1 lysine tyrosylquinone
  • the lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine
• belongs to the lysyl oxidase family

Compartment

secreted

Pathology

• genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome

More general terms

• oxidoreductase
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4016
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4016
• OMIM: https://mirror.omim.org/entry/153456
• OMIM: https://mirror.omim.org/entry/177650
• UniProt: http://www.uniprot.org/uniprot/Q08397.html