alpha-1-fetoprotein (AFP) [Multiple of the median, MOM] adjusted in serum/plasma
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Reference interval
AFP specimen concentration
* M O M = Median AFP concentration for gestational weeks
* M O M = Multiple of the median
AFP values in maternal serum: Maternal serum AFP values from 1,500 unaffected, singleton pregnancies expressed as the regressed median & multiples of the regressed median (MOM) for gestational weeks 15 to 21 are shown in the table below:
| Weeks | Specimens | Median ng/mL | MOM=2.0 | MOM=2.5 | MOM=3.0 |
|---|---|---|---|---|---|
| 15 | 237 | 34.3 | 68.6 | 85.8 | 102.9 |
| 16 | 220 | 39.3 | 78.6 | 98.3 | 117.9 |
| 17 | 217 | 45.1 | 90.2 | 112.8 | 135.3 |
| 18 | 213 | 51.8 | 103.6 | 129.5 | 155.4 |
| 19 | 212 | 59.4 | 118.8 | 48.5 | 178.2 |
| 20 | 201 | 68.2 | 136.4 | 170.5 | 204.6 |
| 21 | 200 | 78.3 | 156.6 | 195.8 | 234.9 |
Clinical significance
- Human serum or plasma & amniotic fluid at 15 to 21 weeks gestation to aid in the detection of fetal open neural tube defects (NTD).
- Test results when used in conjunction with ultrasonography & amniotic fluid acetylcholinesterase testing are a safe & effective aid in the detection of fetal open NTD.
- Maternal serum levels > 2-fold the median should be investigated with ultrasonography.
More general terms
Additional terms
- alpha-1-fetoprotein (AFP) in serum/plasma
- alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin (AFP HPAFP)
References
- ↑ Abbott Laboratories ,Diagnostic Division ,Abbott Park, IL 60064 Tumor Markers, IMx AFP, FEBRUARY 1990.
- ↑ IMx System Operation Manual, Abbott Diagnostics, a Division of Abbott Laboratories, Abbott Park, IL. 60064, AUGUST 1988.
- ↑ IMx System Assay Manual, Abbott Diagnostics, a Division of Abbott Laboratories, Abbott Park, IL. 60064, AUGUST 1988.
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995