lissencephaly type 3

Pathology

• agyria or pachygyria or laminar heterotopia
• abnormalities of corpus callosum, hippocampus, cerebellar vermis & brainstem

Genetics

• associated with defects in TUBA1A

Clinical manifestations

• severe mental retardation
• motor delay
• variable presence of seizures

More general terms

• lissencephaly; agyria