tubulin alpha-1A chain; tubulin B-alpha-1; tubulin alpha-3 chain; alpha-tubulin 3 (TUBA1A, TUBA3)

Function

• tubulin alpha subunit
• undergoes a tyrosination/detyrosination cycle, the cyclic removal & re-addition of a C-terminal Tyr by the enzymes tubulin tyrosine carboxypeptidase (TTCP) & tubulin tyrosine ligase (TTL), respectively (putative)

Structure

• contains 1 non-exchangeable GTP-binding site
• belongs to the tubulin family

Expression

expressed at a high level in fetal brain

Pathology

• defects in TUBA1A are the cause of lissencephaly type 3

More general terms

• tubulin alpha

More specific terms

• tubulin alpha-3D chain; alpha-tubulin 3D; contains:, detyrosinated tubulin alpha-3D chain (TUBA3D)

Additional terms

• tubulin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7846
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7846
• OMIM: https://mirror.omim.org/entry/602529
• OMIM: https://mirror.omim.org/entry/611603
• UniProt: http://www.uniprot.org/uniprot/Q71U36.html