HERV-K 5q33.3 provirus ancestral Pro protein; retrovirus-related protease; HERV-K10 Pro protein; HERV-K107 Pro protein

Function

• this endogenous protein has retained most of the characteristics of retroviral proteases
• this protein is synthesized as Gag-Pro & Gag-Pro-pol polyprotein; these polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro & Pro-pol gene boundaries
• resistant to a number of clinically useful HIV-1 protease inhibitors
• inhibited by cyclic urea SD146
• autoproteolytically processed at the N-terminus

Structure

• belongs to the peptidase A2 family, HERV class-II K(HML-2) subfamily
• contains 1 G-patch domain
• contains 1 peptidase A2 domain

More general terms

• retrovirus-related protease
• aspartic proteinase; carboxyl acid protease

Database

• UniProt: http://www.uniprot.org/uniprot/P10265.html