phosphoinositide-interacting protein (PIRT)

Function

• regulatory subunit of TRPV1, a molecular sensor of noxious heat & capsaicin
• positively regulates TRPV1 channel activity via phosphatidylinositol-4,5-bisphosphate (PIP2)
• binds various phosphoinositide, including phosphatidylinositol-4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI)
• interacts with TRPV1 (putative)

Compartment

membrane (putative)

More general terms

• membrane protein
• protein subunit

Component of

• transient receptor potential cation channel subfamily V member 1; osm-9-like TRP channel 1; vanilloid receptor 1; VR1 capsaicin receptor (TRPV1, OTRPC1)

Database

• OMIM: https://mirror.omim.org/entry/612068
• UniProt: http://www.uniprot.org/uniprot/P0C851.html