myosin 9a; unconventional myosin-9a (MYO9A, MYR7)
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Function
- unconventional myosin
- regulates Rho activity in neurons
- role in the regulation of neuronal morphology & function (putative)
Structure
- contains 5 IQ domains
- contains 2 myosin head-like domains
- contains 2 phorbol-ester/DAG-type Zn+2 fingers
- contains 1 Ras-associating domain
- contains 1 Rho-GAP domain
- lacks the ATP-binding domain which suggests that it cannot interact with actin
Compartment
membrane (putative)
Alternative splicing
named isoforms=5
Expression
- expressed in testis & placenta, & at lower levels in all tissues examined tissues except liver
- isoform 5 was found in leukocytes but not in brain, retina or testis
Pathology
candidate gene for the Bardet-Biedl syndrome