Killin (KLLN)

Function

• DNA-binding protein involved in S phase checkpoint control- coupled apoptosis by mediating p53/TP53-induced apoptosis
• has the ability to inhibit DNA synthesis & induce S phase arrest coupled to apoptosis
• has affinity to both double- & single-stranded DNA

Compartment

nucleus

Expression

by p53/TP53; direct transcription target of p53/TP53

More general terms

• DNA-binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1001
• OMIM: https://mirror.omim.org/entry/612105
• UniProt: http://www.uniprot.org/uniprot/B2CW77.html