Meiosis inhibitor protein 1; Meiosis defective protein 1 (MEI1)

Function

• required for normal meiotic chromosome synapsis
• may be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (putative)

Alternative splicing

named isoforms=7

Expression

• expressed predominantly in testis
• weakly expressed in spleen & thymus

Polymorphism

• genetic variation in MEI1 may predispose European American but not Israeli men to azoospermia by meiotic arrest

More general terms

• uncharacterized protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1503
• OMIM: https://mirror.omim.org/entry/608797
• UniProt: http://www.uniprot.org/uniprot/Q5TIA1.html