primary cutaneous small/medium CD4+ T-cell lymphoma (PCSM-TCL)
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Pathology
- results from CD4+ T-cell proliferation
- high proliferative activity, demonstrated by Ki-67 staining & low CD8+ tumor lymphocytic response characterizes aggressive subgroup that progresses to disseminated disease & death
Clinical manifestations
- frequently presents as a solitary plaque or tumor of 1-3 cm
- favorable clinical prognosis
Laboratory
- complete blood count (CDC)
- intense eosinophilia is a marker of indolent disease
- tissue biopsy Differential diagnsosis
- absence of progression of these lesions from patch to plaque to tumor characterizes PCSM-TCL & distinguishes it from mycosis fungoides
Management
- solitary plaque or tumor of 1-3 cm has a favorable clinical prognosis
- excision, radiotherapy, & topical steroids for indolent solitary lymphomas
- chemotherapy is reserved for the aggressive variant
More general terms
References
- ↑ Garcia-Herrera A et al. Primary cutaneous small/medium CD4+ T-cell lymphomas: A heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol 2008 Jul 10; 26:3364. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18541895