voltage-gated hydrogen channel 1 (hydrogen voltage-gated channel 1, HV1, voltage sensor domain-only protein, HVCN1, VSOP, UNQ578/PRO1140)
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Function
- mediates the voltage-dependent proton permeability of excitable membranes
- forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient
- proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis
Inhibition: inhibited by Zn+2
Structure
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- unlike other voltage-gated ion channels, it lacks the pore domain
- belongs to the hydrogen channel family
Compartment
membrane
Alternative splicing
named isoforms=3
Expression
- enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes & spleen