Serpin-like protein HMSD; minor histocompatibility protein HMSD; minor histocompatibility serpin domain-containing protein (HMSD)

Function

putative serine protease inhibitor (putative)

Structure

belongs to the serpin family

Compartment

secreted (putative)

Alternative splicing

named isoforms=2

• alternative splicing is due 1 intronic SNP

Expression

• highly expressed in dendritic cells & primary leukemia cells, especially those of myeloid lineage

Polymorphism

• minor histocompatibility antigen ACC-6 (mHA ACC-6) is encoded by HMSD-v which is an allelic variant of HMSD

Notes

• translation of HMSD-v form generating mHA ACC-6 is in a frame different from that resulting in HMSD non variant form expression

More general terms

• serine protease inhibitor; serpin
• secreted protein
• glycoprotein

Additional terms

• minor histocompatibility protein HMSD variant form; HSMD-v; contains: minor histocompatibility antigen ACC-6; mHA ACC-6 (HMSD)

Database

• UniProt: http://www.uniprot.org/uniprot/A8MTL9.html