post-GPI attachment to proteins factor 3 (PER1-like domain-containing protein 1, gene coamplified with ERBB2 protein, hCOS16, PERLD1, CAB2, PGAP3, UNQ546/PRO1100)

Function

• role in the lipid remodeling steps of GPI-anchor maturation
• role in metabolism of saturated fatty chains at the sn-2 position of glypiated proteins
• required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (probable)

Structure

belongs to the PGAP3 family

Compartment

• Golgi membrane, endoplasmic reticulum membrane
• mainly localizes to Golgi

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• highest levels in thyroid & placenta

Comparative biology

• when transfected in S.cerevisiae, it can complement the absence of yeast of PER1 protein, suggesting a conserved role in lipid remodeling steps of GPI-anchor maturation

More general terms

• glycoprotein
• transmembrane 7 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9321
• UniProt: http://www.uniprot.org/uniprot/Q96FM1.html