cytochrome P450 4A22 (CYPIVA22, fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase, CYP4A22)
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Function
- catalyzes the omega- & (omega-1)-hydroxylation of various fatty acids such as laurate & palmitate
- no activity towards arachidonic acid & prostaglandin A1
- lacks functional activity in the kidney
- does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis
octane + reduced rubredoxin + O2
<-->
1-octanol + oxidized rubredoxin + H2O
Kinetic parameters:
- KM=56.7 uM for laurate
- Vmax: 15.2 umol/min/umol enzyme
Structure
belongs to the cytochrome P450 family
Compartment
- endoplasmic reticulum membrane, microsome membrane
- peripheral membrane (putative)
Alternative splicing
named isoforms=2
Notes
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q5TCH4.html
- ↑ cytochrome P450 allele Nomenclature committee: CYP4A22 alleles http://www.cypalleles.ki.se/cyp4a22.htm
- ↑ 3.0 3.1 Kawashima H et al, Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. Arch Biochem Biophys. 2000, 378(2):333-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10860550