cytochrome P450 4A11 (fatty acid omega-hydroxylase, P-450 HK omega, lauric acid omega-hydroxylase, CYP4A11, P450-HL-omega)

Function

• catalyzes omega- & (omega-1)-hydroxylation of fatty acids
  • laurate, myristate, palmitate
• little activity towards prostaglandins PGA1 & PGE1

Compartment

membrane-bound, endoplasmic reticulum

Expression

expressed in kidney & liver

Polymorphism

• CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable & not to metabolize lauric acid

More general terms

• cytochrome P450

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1579
• OMIM: https://mirror.omim.org/entry/601310
• UniProt: http://www.uniprot.org/uniprot/Q02928.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1579