RNA polymerase 2 transcription factor SIII subunit A3-like-1 (elongin-A3-like-1, eloA3-like-1, transcription elongation factor B polypeptide 3C-like-1, TCEB3CL)

Function

• SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase 2 transcription elongation past template-encoded arresting sites
• subunit A3 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B & C (elongin BC complex)
• heterotrimer of an A (A1, A2 or A3), B & C subunit

Structure

• elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]
• contains 1 TFIIS N-terminal domain

Compartment

nucleus (putative)

More general terms

• elongin A (EloA)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7289