cinoxacin (Cinobac)

Indications

• treatment of bacterial infections due to susceptible organisms
  • initial & recurrent urinary tract infections in adults

Dosage

• 500 mg PO BID
• at least 2 hours before or 2 hours after antacids containing magnesium or aluminum, iron, or zinc

Dosage adjustment in renal failure

• creatinine clearance (mL/min/1.73 m2)

    > 80: 500 mg BID
   50-80: 250 mg TID
   20-50: 250 mg BID
    < 20: 250 mg QD

Antimicrobial activity

• Escherichia coli
• Proteus mirabilis
• Proteus vulgaris
• Klebsiella species (including K.pneumoniae)
• Enterobacter species

More general terms

• quinolone antibiotic

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2762