high-altitude cerebral edema (HACE)
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Pathology
- vasogenic cerebral edema
- hypoxia-driven increased cerebral blood flow beyond the limits of venous drainage capacity
Clinical manifestations
- symptoms occur 6-90 hours after ascent
- insomnia
- headache
- ataxia
- nausea/vomiting
- lethargy -> obtundation
Management
- immediate return to lower elevation
- supplemental oxygen
- dexamethasone
- acetazolamide may be useful for prevention
More general terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 14, 16, 17, 18. American College of Physicians, Philadelphia 2006, 2012, 2015, 2018.
- ↑ Wilson MH, Hargens AR, Imray CH. Effects of Spaceflight on Astronaut Brain Structure. N Engl J Med 2018; 378:581-583 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29414278 Free full text <Internet> http://www.nejm.org/doi/full/10.1056/NEJMc1716067